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Adenosine Receptors In Neurodegenerative Diseases

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Adenosine Receptors in Neurodegenerative Diseases

Adenosine Receptors in Neurodegenerative Diseases Book
Author : David Blum,Luisa V. Lopes
Publisher : Academic Press
Release : 2017-03-10
ISBN : 0128037458
Language : En, Es, Fr & De

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Book Description :

Adenosine Receptors in Neurodegenerative Diseases covers the role of adenosine receptors in brain function, also focusing on related methodologies and perspectives in therapeutics. The book provides an up-to-date overview by the best specialists in the field, helping readers consider the importance of adenosine and expand the global impact and visibility of adenosine research in the CNS field. Chapters include adenosine biology and signaling, gene regulation, control of motor function, and novel adenosine-based therapies in the CNS. It is an ideal resource for researchers, advanced graduate students, clinicians, and industry scientists working in the fields of clinical neuroscience and molecular and cellular neuroscience. Comprehensive reference that details adenosine receptors in neurodegenerative disorders, with details on brain function and possible therapeutics Gives insights on how these receptors modulate the neurodegenerative outcomes in different disorders Edited by two of the leading researchers in the field regarding adenosine role in the brain in aging and neurodegenerative conditions

Adenosine

Adenosine Book
Author : Susan Masino,Detlev Boison
Publisher : Springer Science & Business Media
Release : 2012-08-30
ISBN : 1461439035
Language : En, Es, Fr & De

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Book Description :

Homeostasis of key metabolites and metabolic health affects all bodily systems. Not surprisingly, altered metabolic function is associated with a wide spectrum of dysfunctions in the central nervous system – including developmental disorders, acute nervous system injury, and neurodegenerative disorders. Accordingly, metabolism-based therapies offer significant promise as new category of treatment options designed to limit, delay or reverse the disease process by reconstructing homeostatic functions. Increasingly it is appreciated that restoring metabolic health could promote normal nervous system activity, and improve behavior and cognition. Adenosine: A Key Link Between Metabolism and Central Nervous System Activity focusses on diverse aspects of adenosine, an evolutionarily conserved homeostatic bioenergetic regulator in the central nervous system. Because of its interrelationship with ATP (adenosine triphosphate), adenosine is integral to cell metabolism. At the same time, adenosine influences neuronal activity directly via receptors, and is involved in biochemical processes related to gene expression. Thus, adenosine is uniquely placed as a reciprocal and rapid link between changes in metabolism and changes in neuronal activity, and, on a longer time scale, to changes in gene expression and long term changes in cell function. Leaders in the field feature basic research on adenosine at the cellular level in the central nervous system, and relate these findings to its recognized potential in diverse acute and chronic disorders. This comprehensive overview of adenosine also highlights emerging adenosine-based treatments and associated opportunities for central nervous system disorders.

Caffeine Adenosine Receptors and Estrogen in Toxin Models of Parkinson s Disease

Caffeine  Adenosine Receptors and Estrogen in Toxin Models of Parkinson s Disease Book
Author : Anonim
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Continued progress has been made toward each of the Specific Aims (SAs) 1 and 2 (SA 3 completed) of our research project, Caffeine, adenosine receptors and estrogen in toxin models of Parkinson's disease (PD) . The overarching hypothesis of the project is that multiple environmental protectants and toxins interact to influence of the health of the dopaminergic neurons lost in PD. To that end we are characterizing the interplay between several environmental agents (pesticides, caffeine and estrogen) that are leading candidate modulators of PD risk. In Year 4 we have obtained and reported evidence that the adenosine receptor blocker caffeine as well as specific genetic depletion of the A2A subtype of adenosine receptor are capable of conferring neuroprotection in chronic pesticide and genetic mouse models of PD. Critical to our ability to successfully pursue the Specific Aims of our research program, we have made technical progress in assessing modification of a key conditional KO methodology developed in this project. We have presented initial data applying this method to the MPTP model of neurodegeneration in PD.

Neuroprotection

Neuroprotection Book
Author : Raymond Chuen-Chung Chang,Yuen-Shan Ho
Publisher : BoD – Books on Demand
Release : 2019-08-28
ISBN : 1789847362
Language : En, Es, Fr & De

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Book Description :

Neuroprotection is a strategy to prevent or delay the progression of chronic neurodegenerative diseases, acute neurological disorders, or even mental disorders. The major aim of this book is to focus on different approaches to achieve neuroprotection. In this book, there are chapters discussing imidazoline ligands and opioid ligands in Alzheimer's disease, the beneficial effects of adenosine A2A receptor antagonist, adrenergic receptor agonists and antagonists modulating microglial responses, and different approaches to achieve neuroprotection against aging-associated macular degeneration. This book will give insights to scientists in the field to stimulate their research, medical professionals to review their clinical practices, and others who would like to learn more about different neuroprotective approaches.

Adenosine Receptors

Adenosine Receptors Book
Author : Gyorgy Hasko,Bruce N. Cronstein,Csaba Szabo
Publisher : CRC Press
Release : 2006-07-20
ISBN : 1420005774
Language : En, Es, Fr & De

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Book Description :

After a century of research, several lines of evidence now indicate that the ability of adenosine to directly control inflammatory cells has a major impact on the functions of the inflammatory and immune systems. Consequently, many promising therapeutic approaches are beginning to emerge that focus on the modulation of adenosine, including the development of compounds that interfere with the breakdown of adenosine, as well as specific agonists and antagonists of various adenosine subtypes. Some of these compounds have already entered clinical trials. While information on the role of adenosine is growing rapidly, until now it has remained scattered in the literature. Edited by three pioneering researchers in the field, Adenosine Receptors: Therapeutic Aspects for Inflammatory and Immune Diseases presents the first single volume compilation of reviews on how adenosine, acting on its cellular receptors, regulates immune responses. The book is organized to provide the reader with a general overview of adenosine receptors, delving into molecular biology, cell biology, and pharmacology. Separate chapters focus on the role of adenosine receptors in regulating the function of the various cell types that are involved in immune responses. Further chapters delineate the role of purinergic signaling in the pathophysiology of a variety of disease states associated with an overzealous or insufficient immune response. These include autoimmune diseases, asthma, atherosclerosis, ischemia-reperfusion injury, and cancer. Much of the methodology and findings documented in this text may well lead to new therapeutic modalities for pathologies such as ischemia and reperfusion, heart disease, wound healing, tumors, pain, and a variety of central nervous system diseases including Parkinson’s, Alzheimer’s, and epilepsy, as well as mood and sleep disorders. This resource provides background and direction for those researchers entering the field of adenosine and inflammatory disease, and provides a comprehensive reference for experienced investigators.

The Adenosine Receptors

The Adenosine Receptors Book
Author : Pier Andrea Borea,Katia Varani,Stefania Gessi,Stefania Merighi,Fabrizio Vincenzi
Publisher : Humana Press
Release : 2018-07-28
ISBN : 3319908081
Language : En, Es, Fr & De

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Book Description :

This book traces the history of adenosine receptor research from molecular biology to medicinal chemistry to behavior, including their implications in disease and potential strategies as therapeutic targets. It provides the reader with a comprehensive overview of the adenosine receptors that includes information on all subtypes - A1, A2A, A2B and A3. Aspects addressed include the most up to date information on their functional distribution in the nervous and peripheral systems, behavioral roles in inflammation, cancer, pain and neurological diseases such as Huntington’s disease, Epilepsy, Parkinson’s disease and Alzheimer’s disease.

Neuroprotective Roles of the P2Y2 Nucleotide Receptor

Neuroprotective Roles of the P2Y2 Nucleotide Receptor Book
Author : Christina N. Thebeau
Publisher : Unknown
Release : 2014
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Purinergic signaling plays a unique role in the brain by integrating neuronal and glial cellular circuits. The metabotropic P1 adenosine receptors and P2Y nucleotide receptors and ionotropic P2X receptors control numerous physiological functions of neuronal and glial cells and have been implicated in a wide variety of neuropathologies. Emerging research suggests that purinergic receptor interactions between cells of the central nervous system (CNS) have relevance in the prevention and attenuation of neurodegenerative diseases resulting from chronic inflammation. CNS responses to chronic inflammation are largely dependent on interactions between different cell types (i.e., neurons and glia) and P2X and P2Y receptors. Whereas numerous P2 receptors contribute to functions of the CNS, the P2Y2R is believed to play an important role in neuroprotection under inflammatory conditions. While acute inflammation is necessary for tissue repair due to injury, chronic inflammation contributes to neurodegeneration in Alzheimer's disease (AD) and occurs when glial cells undergo prolonged activation resulting in extended release of proinflammatory cytokines and nucleotides. This review describes cell-specific and tissue-integrated functions of P2 receptors in the CNS with an emphasis on P2Y2R signaling pathways in neurons, glia and endothelium and their role in neuroprotection.

Omic Studies of Neurodegenerative Disease Part B

Omic Studies of Neurodegenerative Disease   Part B Book
Author : Anonim
Publisher : Academic Press
Release : 2015-11-23
ISBN : 0128047631
Language : En, Es, Fr & De

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Book Description :

Omic Studies of Neurodegenerative Disease: Part B is part of a well-established international series on neuroscience that examines major areas of basic and clinical research, along with emerging and promising subfields. The book informs the reader on the current state of the studies used to evaluate the mechanisms, causes, and treatment of neurodegeneration through a combination of literature reviews and examples of current research. Provides the expertise of leading contributors in the field Demonstrates how findings in the fields of genomics, proteomics, and metabolomic studies can combined for further insights Informs the reader on the current state of the studies used to study the mechanisms, causes, and treatment of neurodegeneration through a combination of literature reviews and examples of current research

Omic Studies of Neurodegenerative Disease

Omic Studies of Neurodegenerative Disease   Book
Author : Anonim
Publisher : Academic Press
Release : 2015-08-25
ISBN : 0128016213
Language : En, Es, Fr & De

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Book Description :

Omic Studies of Neurodegenerative Disease: Part A is part of a well-established international series on neuroscience that examines major areas of basic and clinical research, along with emerging and promising subfields. The book informs the reader on the current state of the studies used to evaluate the mechanisms, causes, and treatment of neurodegeneration through a combination of literature reviews and examples of current research. Provides the expertise of leading contributors in the field Demonstrates how findings in the fields of genomics, proteomics, and metabolomic studies can combined for further insights Informs the reader on the current state of the studies used to study the mechanisms, causes, and treatment of neurodegeneration through a combination of literature reviews and examples of current research

International Review of Neurobiology

International Review of Neurobiology Book
Author : Ronald J. Bradley,R. Adron Harris,Peter Jenner
Publisher : Elsevier
Release : 2005-04-04
ISBN : 9780080458311
Language : En, Es, Fr & De

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Book Description :

Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.

Neuroinflammation Induces Time dependant Behavioral Cellular and Molecular Changes that Resemble Characteristics of Alzheimer s and Parkinson s Diseases and Can be Modulated by Caffeine Administration

Neuroinflammation Induces Time dependant Behavioral  Cellular and Molecular Changes that Resemble Characteristics of Alzheimer s and Parkinson s Diseases and Can be Modulated by Caffeine Administration Book
Author : Holly Marie Brothers
Publisher : Unknown
Release : 2010
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Abstract: Chronic neuroinflammation is a common characteristic of neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases, that may contribute to loss of function and cell death. Cell loss in the hippocampus and cortex is characteristic of Alzheimer's disease (AD), Parkinson's disease (PD) is marked by the loss of cells in the substantia nigra (SN), and both the locus coeruleus (LC) and the raphe nucleus are known to be affected in these diseases. Caffeine, an adenosine antagonist, is protective against the risk of AD and PD. The experiments described in this thesis were designed to address the following two hypotheses: If neuroinflammation contributes to the onset/progression of behavioral, cellular and molecular characteristics of AD and PD in a time-dependant manner in the temporal lobe and brainstem, then neuroinflammation created in a young rat by i.c.v. infusion of LPS should reproduce a subset of time-dependant characteristics of AD and PD in these brain regions. If the actions of adenosine at its receptors contribute to the behavioral, cellular and molecular characteristics of AD and PD reproduced by LPS-induced neuroinflammation and natural aging in rats, then modulation of the consequences of neuroinflammation by the adenosine receptor antagonist caffeine should attenuate the disease-like characteristics produced by neuroinflammation and aging. In order to test these hypotheses, young rats (3 months) were implanted with a cannula into the IVth ventricle that was connected to an osmotic minipump filled with either lipopolysaccharide (LPS) or the vehicle (aCSF) for 2, 4 or 8 weeks and modulation by caffeine upon experimentally produced neuroinflammation in LPS-infused young rats and naturally occurring inflammation in aged rats was evaluated. We predicted that LPS-infusion would produce microglia activation (defined as presentation of MHC II) in the hippocampus and brainstem, regions that degenerate in AD and PD, that would increase in intensity over time, evidence of reduced function and potentially death of dopaminergic neurons within the SN that would also increase with time, and corresponding behavioral deficits. Furthermore, we predicted that caffeine, a drug with known epidemiological potential to reduce the incidence of both AD and PD, would attenuate the development of neuroinflammation and the behavioral, cellular and molecular consequences of inflammation in a dose-dependent manner. The infusion of LPS induced pronounced microglia activation and characteristic changes in morphology that increased with the duration of LPS infusion. The regional distribution of microglia presenting MHC II is heterogeneous and was concentrated in the DG of the hippocampus, SN, LC and raphe as compared to other regions, indicating that those regions most vulnerable to degeneration in a disease state are those with the greatest propensity to develop reactive microglia to an inflammagen. Rats that received LPS performed poorly in the Morris water maze, a task known to be sensitive to the integrity of the hippocampus. LPS-infused rats also displayed reduced production of tyrosine hydroxylase and therefore reduced dopamine synthesis in the SN and displayed dysmorphic neuronal structure in LC and the raphe nucleus.

Methylxanthines

Methylxanthines Book
Author : Bertil B. Fredholm
Publisher : Springer Science & Business Media
Release : 2010-09-22
ISBN : 9783642134432
Language : En, Es, Fr & De

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Book Description :

In the present volume of the Handbook of Experimental Pharmacology well known experts describe the actions of different xanthines with a focus on caffeine and theophylline. A special chapter is devoted to theobromine, an active component of chocolate, the actions of which are less well characterized. This book also presents the pharmacology of one xanthine derivative, propentofylline, as an example of a xanthine that has gone through extensive development for a novel therapeutic area.

Adenosine Receptors in Neurology and Psychiatry

Adenosine Receptors in Neurology and Psychiatry Book
Author : Anonim
Publisher : Academic Press
Release : 2014-08-28
ISBN : 0128013184
Language : En, Es, Fr & De

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Book Description :

This well-established international series examines major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields. This volume concentrates on adenosine receptor science, providing insights useful for actual drug discovery/development in neurology and psychiatry areas. Expertise of contributors Subject including practical drug development from basic science, as translational research taste Structure of contents focusing on two CNS areas for diseases (neurology and psychiatry)

The Handbook of Neuroprotection

The Handbook of Neuroprotection Book
Author : Kewal K. Jain
Publisher : Springer
Release : 2019-05-15
ISBN : 1493994654
Language : En, Es, Fr & De

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Book Description :

This fully revised edition explores the management of neurological disorders with a focus on neuroprotection, disease modification, and neuroregeneration rather than symptomatic treatment. Since the publication of the first edition, advances in biotechnology, particularly in cell and gene therapies, are reflected in this volume, as are numerous new and repurposed drugs in clinical trials. Overall, The Handbook of Neuroprotection serves as a comprehensive review of neuroprotection based on knowledge of the molecular basis of disorders of the central nervous system. In-depth and authoritative, The Handbook of Neuroprotection, Second Edition features a compendium of vital knowledge aimed at providing researchers with an essential reference for this key neurological area of study.

Recent Advances in Parkinsons Disease

Recent Advances in Parkinsons Disease Book
Author : Anonim
Publisher : Elsevier
Release : 2010-08-20
ISBN : 0444536248
Language : En, Es, Fr & De

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Book Description :

This first volume starts with an overview on current perspectives in genetic research and on the molecular mechanisms of neurodegeneration. This is followed by a selection of hot topics in pathophysiological research, from molecular studies to system-level investigations based on in vivo electrophysiological recordings and neurocomputational methods. Complete overview of hot topics and approaches to current PD research, from molecules, to brain circuits, to clinical and therapeutic applications. Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research. All chapters include comprehensive background information and are written in a clear form that is accessible also to the non-specialist.

Neuroglia in Neurodegenerative Diseases

Neuroglia in Neurodegenerative Diseases Book
Author : Alexei Verkhratsky,Margaret S. Ho,Robert Zorec,Vladimir Parpura
Publisher : Springer Nature
Release : 2019-10-03
ISBN : 9811399131
Language : En, Es, Fr & De

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Book Description :

This book provides a comprehensive overview of the role of neuroglia in neurodegenerative diseases. Neuroglia are the most abundant cells in the nervous system and consist of several distinct cell types, such as astrocytes, oligodendrocytes,and microglia. Accumulating evidence suggests that neuroglia participate in the neurodegenerative process, and as such are essential players in a variety of diseases, including Alzheimer’s, Parkinson’s, and Huntington’s. Intended for researchers and students, the book presents recent advances concerning the biology of neuroglia as well as their interaction with neurons during disease progression. In addition, to highlight the function of neuroglia in different types of neurodegenerative disease, it also discusses their mechanisms and effects on protecting or damaging neurons.

Purinergic Pharmacology

Purinergic Pharmacology Book
Author : Francisco Ciruela,Kenneth A. Jacobson
Publisher : Frontiers Media SA
Release : 2019-08-16
ISBN : 2889459470
Language : En, Es, Fr & De

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Book Description :

Download Purinergic Pharmacology book written by Francisco Ciruela,Kenneth A. Jacobson, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Glial Cells Maladaptive Plasticity and Neurodegeneration Mechanisms Targeted Therapies and Future Directions

Glial Cells  Maladaptive Plasticity and Neurodegeneration  Mechanisms  Targeted Therapies and Future Directions Book
Author : Giovanni Cirillo,Andrea Beatriz Cragnolini,Livio Luongo
Publisher : Frontiers Media SA
Release : 2021-06-17
ISBN : 2889669378
Language : En, Es, Fr & De

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Book Description :

Download Glial Cells Maladaptive Plasticity and Neurodegeneration Mechanisms Targeted Therapies and Future Directions book written by Giovanni Cirillo,Andrea Beatriz Cragnolini,Livio Luongo, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics

A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics Book
Author : Pier Andrea Borea
Publisher : Springer Science & Business Media
Release : 2009-12-01
ISBN : 9789048131440
Language : En, Es, Fr & De

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Book Description :

This book, with its 16 chapters, documents the present state of knowledge of the adenosine A receptor. It covers a wide range of information, including data from 3 studies of theoretical, molecular and cellular pharmacology, signal transduction, integrative physiology, new drug discoveries and clinical applications. It fills an important gap in the literature since no alternative source of such information is currently available. Although the A receptor is increasingly being recognized for 3 its increasing number of biological roles throughout the body and many A receptor 3 ligands have proven useful in elucidating peripheral and central pathologies, many issues remain unresolved. Moreover, research activity in this field continues to grow exponentially, resulting in a constant flow of new information. The chapters in this book cover both basic science and the relevant applications and provide an authoritative account of the current status of the field. They have enabled my goal as editor to make “A Adenosine Receptors from Cell Biology to Pharmacology and 3 Therapeutics” an up to date, scientifically excellent, reference source, attractive to basic and clinical scientists alike, a reality. Detailed understanding of the physico-chemical aspects and molecular biology of the A receptor provides a solid basis for its future development as a target for 3 adenosine-based pharmacotherapies (Chapters 2 and 3).

CSA Neurosciences Abstracts

CSA Neurosciences Abstracts Book
Author : Anonim
Publisher : Unknown
Release : 1998
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download CSA Neurosciences Abstracts book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.