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A Paradigm Shift To Prevent And Treat Alzheimers Disease

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A Paradigm Shift to Prevent and Treat Alzheimer s Disease

A Paradigm Shift to Prevent and Treat Alzheimer s Disease Book
Author : Howard Friel,Sally A. Frautschy
Publisher : Academic Press
Release : 2017-07-18
ISBN : 012812279X
Language : En, Es, Fr & De

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Book Description :

A Paradigm Shift to Prevent and Treat Alzheimer’s Disease: From Monotargeting Pharmaceuticals to Pleiotropic Plant Polyphenols is the first book to systematically exhibit the powerful pleiotropic pharmacological effects on Alzheimer’s disease of plant-based compounds from ancient foods that humans have been consuming safely with substantial health benefits for thousands of years. These plant-based compounds include curcuminoids from turmeric, resveratrol from red wine and grape seed extract from other grape products, epigallocatechin-gallate (EGCG) from green tea, and oleocanthal and oleuropein from olive oil, in addition to a special extract, EGb 761, from the leaves of Ginkgo biloba, the oldest living species of tree on earth. This book also presents a new analytical framework that convincingly favors a multi-targeting ("pleiotropic") approach to the prevention and treatment of complex chronic diseases, in contrast to the mono-targeting of the pharmaceutical model. A Paradigm Shift to Prevent and Treat Alzheimer’s Disease is a unique and exciting resource for pharmaceutical scientists, pharmacologists, neurologists, general practitioners, research scientists in various medical and life sciences, healthcare professionals in clinical and executive positions, conventional medical schools, schools of naturopathic medicine, healthcare and medical journalists, executives in both national public healthcare systems and private insurers, and informed general readers. Presents carefully compiled evidence supporting the need to shift from pharmaceutical-based mono-targeting to plant polyphenol-based pleiotropic targeting for the prevention and treatment of Alzheimer’s disease Includes valuable tables that aggregate pleiotropic pharmacological effects of the plant polyphenols on Alzheimer’s disease-related pathogenic hallmarks Highlights regulatory aspects and discusses the challenges and potential solutions with respect to bioavailability of certain plant polyphenols

ABC s of Alzheimers Disease

ABC s of Alzheimers Disease Book
Author : Bruce Bauer
Publisher : Covenant Books, Inc.
Release : 2019-05-23
ISBN : 1643009494
Language : En, Es, Fr & De

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Book Description :

ABCs of Alzheimer's Disease: a Shared Reality by Me and My Shadow is a story of Bruce and Ethel's Alzheimer's disease (AD) journey, along with a history of AD from autopsies to PET scan research, including technology and genetic discoveries. The book is a realistic, short, comprehensive, evidence-based, description of Alzheimer's disease (AD). It describes AD research, including clinical trials, a simplified understanding of the brain, and the experiences of patient/caregiver persistence and journey as well as hope for the future research possibilities through worldwide basic science, biology, genetic, mathematics, and technology evolution and discoveries. In addition, it identifies AD issues, uncertainties, and author's comments, along with "outside the box" ideas for governance to provide leadership for the coming Alzheimer's disease tsunami. With the future facing an AD tsunami and potential shortage of care personnel, the book provides potential for education and/or training for candidate patients, caregivers, primary care doctors, nurses, physician assistants, license nurse practitioners, certified nurse assistant, institutional care personnel, in-home health personnel, hospital personnel, educators, and politicians. In addition, this book could be a supplement document for geriatric schooling as well as an enlightening and educating source for political leaders (all three branches of government) and their staffs. The book describes a stage by stage behavior symptoms tied to cognitive measures and Alzheimer Association warning signs, along with suggestions for caregiver, relative to patient's state of decline. The book addresses why clinical trials have been failing and why hope for delay and prevention may be forthcoming as well as the 2011 paradigm shift and current presymptomatic candidacy. Clinical trials adventures, along with a suggestion to eliminate the placebo cohort group are described. So, what does the future hold for Alzheimer's disease-hope, promises, delay, prevention, or cure? These are all wants. What is reality? Moving research targets are being addressed and pursued with evolving knowledge and tools. This evolution will probably make current targets obsolete in twenty years. For reality, you be the judge after reading this book. "Out the box" ideas are provided that require governance action for confronting the coming AD tsunami and associated diversity care.

Comprehensive Medicinal Chemistry III

Comprehensive Medicinal Chemistry III Book
Author : Anonim
Publisher : Elsevier
Release : 2017-06-03
ISBN : 0128032014
Language : En, Es, Fr & De

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Book Description :

Comprehensive Medicinal Chemistry III provides a contemporary and forward-looking critical analysis and summary of recent developments, emerging trends, and recently identified new areas where medicinal chemistry is having an impact. The discipline of medicinal chemistry continues to evolve as it adapts to new opportunities and strives to solve new challenges. These include drug targeting, biomolecular therapeutics, development of chemical biology tools, data collection and analysis, in silico models as predictors for biological properties, identification and validation of new targets, approaches to quantify target engagement, new methods for synthesis of drug candidates such as green chemistry, development of novel scaffolds for drug discovery, and the role of regulatory agencies in drug discovery. Reviews the strategies, technologies, principles, and applications of modern medicinal chemistry Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs

Developing Therapeutics for Alzheimer s Disease

Developing Therapeutics for Alzheimer s Disease Book
Author : Michael S. Wolfe
Publisher : Academic Press
Release : 2016-05-27
ISBN : 0128021640
Language : En, Es, Fr & De

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Book Description :

Developing Therapeutics for Alzheimer's Disease: Progress and Challenges provides a thorough overview of the latest advances toward the development of therapeutics for Alzheimer’s disease, along with the major hurdles that still must be overcome and potential solutions to these problems. Despite the lack of progress toward developing therapeutics that can slow or stop the progression of this disease, important discoveries have been made and many promising approaches are advancing in preclinical studies and clinical trials. This book outlines the special challenges related to specific targets and approaches, while presenting a realistic, comprehensive and balanced view of drug discovery and development in this area. Written by international leaders in the field, the book assesses prospects for the emergence of effective agents and allows readers to better understand the challenges, failures, and future potential for research in Alzheimer’s disease. This book is a valuable resource to academic scientists carrying out translational research in Alzheimer’s disease, industrial scientists engaged in Alzheimer's drug discovery, executives in biopharmaceutical companies making strategic decisions regarding the direction of internal research and potential outside partnerships, and graduate-level students pursuing courses on Alzheimer's therapeutics. Provides a realistic but promising assessment of the potential of various therapeutic approaches to Alzheimer’s disease Focuses primarily on neuroprotective agents and cognitive enhancers, as well as approaches to targeting the amyloid B-peptide, tau and Apolipoprotein E Discusses alternative approaches, preclinical and clinical development issues, related biomarkers and diagnostics, and prevention and nonpharmacological approaches

Oxford Textbook of Public Mental Health

Oxford Textbook of Public Mental Health Book
Author : Dinesh Bhugra,Kamaldeep Bhui,Samuel Yeung Shan Wong,Stephen E. Gilman
Publisher : Oxford University Press
Release : 2018-09-13
ISBN : 0192511408
Language : En, Es, Fr & De

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Book Description :

Prevention of mental illness and mental health promotion have often been ignored in the past, both in undergraduate and postgraduate curricula. Recently, however, there has been a clear shift towards public mental health, as a result of increasing scientific evidence that both these actions have a serious potential to reduce the onset of illness and subsequent burden as a result of mental illness and related social, economic and political costs. A clear distinction between prevention of mental illness and mental health promotion is critical. Selective prevention, both at societal and individual level, is an important way forward. The Oxford Textbook of Public Mental Health brings together the increasing interest in public mental health and the growing emphasis on the prevention of mental ill health and promotion of well-being into a single comprehensive textbook. Comprising international experiences of mental health promotion and mental well-being, chapters are supplemented with practical examples and illustrations to provide the most relevant information succinctly. This book will serve as an essential resource for mental and public health professionals, as well as for commissioners of services, nurses and community health visitors.

Phytomedicine and Alzheimer s Disease

Phytomedicine and Alzheimer   s Disease Book
Author : Atanu Bhattacharjee,Akula Ramakrishna,M. Obulesu
Publisher : CRC Press
Release : 2020-10-26
ISBN : 1000171388
Language : En, Es, Fr & De

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Book Description :

Alzheimer's disease, one of the most rapidly growing neurodegenerative disorders, is characterized by a progressive loss of memory. Despite several advances in the field of medical therapeutics, a viable treatment for Alzheimer's disease would be of great importance. Medicinal plants represent a largely untapped reservoir of natural medicines and potential sources of anti-Alzheimer’s drugs. The structural diversity of their phytoconstituents makes these plants a valuable source of novel lead compounds in the quest for drugs to treat Alzheimer's disease. Based on traditional literature and up-to-date research, various new therapeutically active compounds have been identified from phytoextracts, which could be useful in the treatment of cognitive disorders. Phytomedicine and Alzheimer’s Disease presents information on Mechanistic aspects of neurodegeneration in Alzheimer’s disease and the role of phytochemicals as restorative agents Understanding the complex biochemical aspects of Alzheimer’s disease Pre-clinical approaches to evaluating drugs to target Alzheimer’s disease Assessing alternative approaches to treating Alzheimer’s disease and the role of alternative medicine to delay the symptomatic progression of this disease Epigenetic changes in Alzheimer’s disease and possible therapeutic or dietary interventions This book serves as an excellent resource for scientific investigators, academics, biochemists, botanists, and alternative medicine practitioners who work to advance the role of phytomedicines in treating Alzheimer’s disease.

Bioimaging in Neurodegeneration

Bioimaging in Neurodegeneration Book
Author : Patricia A. Broderick,David N. Rahni,Edwin H. Kolodny
Publisher : Springer Science & Business Media
Release : 2007-11-05
ISBN : 1592598889
Language : En, Es, Fr & De

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Book Description :

Bioimaging is in the forefront of medicine for the diagnosis and helps to predict the progression of AD via mild cognitive treatment of neurodegenerative disease. Conventional magnetic impairment (MCI) studies. resonance imaging (MRI) uses interactive external magnetic fields Novel neuroimaging technologies, such as neuromolecular and resonant frequencies of protons from water molecules. imaging (NMI) with a series of newly developed BRODERICK ® However, newer sequences, such as magnetization-prepared rapid PROBE sensors, directly image neurotransmitters, precursors, acquisition gradient echo (MPRAGE), are able to seek higher and metabolites in vivo, in real time and within seconds, at separate levels of anatomic resolution by allowing more rapid temporal and selective waveform potentials. NMI, which uses an imaging. Magnetic resonance spectroscopy (MRS) images electrochemical basis for detection, enables the differentiation of metabolic changes, enabling underlying pathophysiologic neurodegenerative diseases in patients who present with mesial dysfunction in neurodegeneration to be deciphered. Neuro- versus neocortical temporal lobe epilepsy. In fact, NMI has some 1 chemicals visible with proton H MRS include N-acetyl aspartate remarkable similarities to MRI insofar as there is technological (NAA), creatine/phosphocreatine (Cr), and choline (Cho); NAA dependence on electron and proton transfer, respectively, and is considered to act as an in vivo marker for neuronal loss and/or further dependence is seen in both NMI and MRI on tissue neuronal dysfunction. By extending imaging to the study of composition such as lipids.

Neurodegeneration

Neurodegeneration Book
Author : Ted M. Dawson
Publisher : John Wiley & Sons
Release : 2017-04-24
ISBN : 0470672684
Language : En, Es, Fr & De

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Book Description :

This book unites the diverse range of complex neurodegenerative diseases into a textbook designed for clinical practice, edited by globally leading authorities on the subject. Presents a clinically oriented guide to the diseases caused by neurodegeneration Templated chapters combine clinical and research information on neurodegenerative diseases beginning with the common elements before treating each disease individually Diseases are grouped by anatomical regions of degeneration and include common disorders such as Parkinson’s Disease, Alzheimer’s Disease, Amyotrophic Lateral Sclerosis/Motor Neuron Disease, and Multiple Sclerosis as well as less common diseases Edited by globally leading authorities on the subject, and written by expert contributing authors

Neurology for the Non Neurologist An Issue of Medical Clinics of North America Ebook

Neurology for the Non Neurologist  An Issue of Medical Clinics of North America  Ebook Book
Author : Tracey A Milligan
Publisher : Elsevier Health Sciences
Release : 2019-01-31
ISBN : 032365472X
Language : En, Es, Fr & De

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Book Description :

This issue of Medical Clinics, Guest Edited by Dr. Tracey A. Milligan, is devoted to Neurology. Articles in this issue include: Diagnosis of Neurologic Disorders; Dementia: Diagnosis and Treatment; Cerebrovascular Disease: Primary and Secondary Prevention; Seizures and Epilepsy; Migraine; Multiple Sclerosis and Autoimmune Neurology: Autoimmune Disease of the Brain and Spinal Cord; Concussion Evaluation and Management; Parkinsonism and Tremor; Compression and Entrapment Neuropathies; Peripheral Neuropathies; Falls and Gait Disorders; Nonmigraine Headache and Facial Pain; and Examination of the Dizzy Patient.

Functional Foods for Chronic Diseases

Functional Foods for Chronic Diseases Book
Author : Danik M. Martirosyan
Publisher : D&A Inc.
Release : 2006-07
ISBN : 9780976753520
Language : En, Es, Fr & De

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Book Description :

Chronic diseases sych as cardiovascular, cancer, diabetes and obesity are a global epidemic in various developed countries and there is an unprecedented level of interest in this area of research. This book represents a collection of selected reviews on modern approaches in herbal remedies, food additives, and non-traditional plants. The contribution of varios scientists from different parts of the world, including participants in an international conference entitled, "Functional Foods for the Prevention and Treatment of Chronic Diseases," compose this book. The main goal of this book is to bring together experts in medicine, biology, and the food industry to present the contributions of functional food products in the prevention and treatment of chronic diseases.

Principles of Drug Therapy in Neurology

Principles of Drug Therapy in Neurology Book
Author : Michael V. Johnston,Robert Gross
Publisher : Oxford University Press
Release : 2008-05
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Since the first edition of this book was published in 1992, the number of pharmacological therapies available for treating neurological disorders has grown exponentialy. This new edition brings the book fully up-to-date, and features PET scans to illustrate brain action, and new chapters on practical therapeutics and clinical trials.

Dying in America

Dying in America Book
Author : Institute of Medicine,Committee on Approaching Death: Addressing Key End-of-Life Issues
Publisher : National Academies Press
Release : 2015-03-19
ISBN : 0309303133
Language : En, Es, Fr & De

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Book Description :

For patients and their loved ones, no care decisions are more profound than those made near the end of life. Unfortunately, the experience of dying in the United States is often characterized by fragmented care, inadequate treatment of distressing symptoms, frequent transitions among care settings, and enormous care responsibilities for families. According to this report, the current health care system of rendering more intensive services than are necessary and desired by patients, and the lack of coordination among programs increases risks to patients and creates avoidable burdens on them and their families. Dying in America is a study of the current state of health care for persons of all ages who are nearing the end of life. Death is not a strictly medical event. Ideally, health care for those nearing the end of life harmonizes with social, psychological, and spiritual support. All people with advanced illnesses who may be approaching the end of life are entitled to access to high-quality, compassionate, evidence-based care, consistent with their wishes. Dying in America evaluates strategies to integrate care into a person- and family-centered, team-based framework, and makes recommendations to create a system that coordinates care and supports and respects the choices of patients and their families. The findings and recommendations of this report will address the needs of patients and their families and assist policy makers, clinicians and their educational and credentialing bodies, leaders of health care delivery and financing organizations, researchers, public and private funders, religious and community leaders, advocates of better care, journalists, and the public to provide the best care possible for people nearing the end of life.

Pathology E Book

Pathology   E Book Book
Author : Catherine C. Goodman,Kenda S. Fuller
Publisher : Elsevier Health Sciences
Release : 2014-11-05
ISBN : 0323291228
Language : En, Es, Fr & De

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Book Description :

Understand how a patient’s conditions might affect physical therapy and outcomes so that you can design safe and effective interventions. The only pathology textbook written specifically for physical therapists, Pathology: Implications for the Physical Therapist, Third Edition, offers guidelines, precautions, and contraindications for interventions with patients who have musculoskeletal or neuromuscular problems as well as other conditions such as diabetes, heart disease, or pancreatitis. Learn about the cause of these conditions, the pathogenesis, medical diagnosis and treatment, and most importantly, the special implications for the therapist. In addition to addressing specific diseases and conditions, this text emphasizes health promotion and disease prevention strategies and covers issues with implications for physical therapy management, such as injury, inflammation, and healing; the lymphatic system; and biopsychosocial–spiritual impacts on health care. With this practical and evidence-based text, now enhanced with full-color illustrations and the latest research, you’ll know what to factor into your clinical decisions to achieve the best outcomes for your patients. Incorporates the Medical Model, the Disablement Model, and the ICF Model Incorporates Preferred Practice Patterns from the Guide to Physical Therapist Practice, Second Edition throughout the text Presents key information in at-a-glance format that is organized by body system for easy reference Provides the basic science information and the clinical implications of disease within the rehabilitation process, covering common illnesses and diseases, adverse effects of drugs, organ transplantation, laboratory values, and much more Focuses on health promotion and disease prevention throughout “Special Implications for the Therapist sections present the most likely practice patterns associated with each disease or disorder and address precautions, contraindications, and considerations specific to PTs. Current information on conditions, medical testing and treatment, and practice models keeps you up-to-date on the latest research findings and recent changes in the field. Companion Evolve site provides easy access to articles referenced in the text with links to Medline. Tables and text boxes throughout the text summarize important information and highlight key points.

Dementia Care

Dementia Care Book
Author : Marie Boltz,James E. Galvin
Publisher : Springer
Release : 2015-09-29
ISBN : 331918377X
Language : En, Es, Fr & De

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Book Description :

This book provides an overview of the demographic, clinical, and psychosocial context of dementia care. With its focus on patient and family perspectives, this book describes evidence-based approaches towards prevention, detection, and treatment of dementia that is like any other book. The text presents memory clinics, care management, home-based interventions, palliative care, family caregiver programs, specific to dementia care. Additionally, the text examines strategies to support transitions to acute care and long-term care. The text also places a special emphasis on measures of quality, cultural sensitivity, and implications for health care policy. Written by experts in the field, Dementia Care: An Evidence-Based Approach is an excellent resource for clinicians, students, healthcare administrators, and policymakers who aim to improve the quality of life of both the person with dementia and their informal caregiver.

The Alzheimer Conundrum

The Alzheimer Conundrum Book
Author : Margaret Lock
Publisher : Princeton University Press
Release : 2015-10-20
ISBN : 0691168474
Language : En, Es, Fr & De

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Book Description :

Due to rapidly aging populations, the number of people worldwide experiencing dementia is increasing, and the projections are grim. Despite billions of dollars invested in medical research, no effective treatment has been discovered for Alzheimer's disease, the most common form of dementia. The Alzheimer Conundrum exposes the predicaments embedded in current efforts to slow down or halt Alzheimer’s disease through early detection of pre-symptomatic biological changes in healthy individuals. Based on a meticulous account of the history of Alzheimer’s disease and extensive in-depth interviews, Margaret Lock highlights the limitations and the dissent associated with biomarker detection. Lock argues that basic research must continue, but should be complemented by a public health approach to prevention that is economically feasible, more humane, and much more effective globally than one exclusively focused on an increasingly harried search for a cure.

Neurobiology of Mental Illness

Neurobiology of Mental Illness Book
Author : Dennis S. Charney,Eric J. Nestler,Pamela Sklar,Joseph D. Buxbaum
Publisher : Oxford University Press
Release : 2013-07-04
ISBN : 0199934959
Language : En, Es, Fr & De

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Book Description :

Our understanding of the neurobiological basis of psychiatric disease has accelerated in the past five years. The fourth edition of Neurobiology of Mental Illness has been completely revamped given these advances and discoveries on the neurobiologic foundations of psychiatry. Like its predecessors the book begins with an overview of the basic science. The emerging technologies in Section 2 have been extensively redone to match the progress in the field including new chapters on the applications of stem cells, optogenetics, and image guided stimulation to our understanding and treatment of psychiatric disorders. Sections' 3 through 8 pertain to the major psychiatric syndromes-the psychoses, mood disorders, anxiety disorders, substance use disorders, dementias, and disorders of childhood-onset. Each of these sections includes our knowledge of their etiology, pathophysiology, and treatment. The final section discusses special topic areas including the neurobiology of sleep, resilience, social attachment, aggression, personality disorders and eating disorders. In all, there are 32 new chapters in this volume including unique insights on DSM-5, the Research Domain Criteria (RDoC) from NIMH, and a perspective on the continuing challenges of diagnosis given what we know of the brain and the mechanisms pertaining to mental illness. This book provides information from numerous levels of analysis including molecular biology and genetics, cellular physiology, neuroanatomy, neuropharmacology, epidemiology, and behavior. In doing so it translates information from the basic laboratory to the clinical laboratory and finally to clinical treatment. No other book distills the basic science and underpinnings of mental disorders and explains the clinical significance to the scope and breadth of this classic text. The result is an excellent and cutting-edge resource for psychiatric residents, psychiatric researchers and doctoral students in neurochemistry and the neurosciences.

Brocklehurst s Textbook of Geriatric Medicine and Gerontology E Book

Brocklehurst s Textbook of Geriatric Medicine and Gerontology E Book Book
Author : Howard M. Fillit,Kenneth Rockwood,John B Young
Publisher : Elsevier Health Sciences
Release : 2016-05-06
ISBN : 0702063444
Language : En, Es, Fr & De

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Book Description :

The leading reference in the field of geriatric care, Brocklehurst’s Textbook of Geriatric Medicine and Gerontology, 8th Edition, provides a contemporary, global perspective on topics of importance to today’s gerontologists, internal medicine physicians, and family doctors. An increased focus on frailty, along with coverage of key issues in gerontology, disease-specific geriatrics, and complex syndromes specific to the elderly, makes this 8th Edition the reference you’ll turn to in order to meet the unique challenges posed by this growing patient population. Consistent discussions of clinical manifestations, diagnosis, prevention, treatment, and more make reference quick and easy. More than 250 figures, including algorithms, photographs, and tables, complement the text and help you find what you need on a given condition. Clinical relevance of the latest scientific findings helps you easily apply the material to everyday practice. A new chapter on frailty, plus an emphasis on frailty throughout the book, addresses the complex medical and social issues that affect care, and the specific knowledge and skills essential for meeting your patients’ complex needs. New content brings you up to date with information on gerontechnology, emergency and pre-hospital care, HIV and aging, intensive treatment of older adults, telemedicine, the built environment, and transcultural geriatrics. New editor Professor John Young brings a fresh perspective and unique expertise to this edition.

Resources in education

Resources in education Book
Author : Anonim
Publisher : Unknown
Release : 1992-02
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Resources in education book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Lifetime Physical Fitness and Wellness

Lifetime Physical Fitness and Wellness Book
Author : Wener W.K. Hoeger,Sharon A. Hoeger,Cherie I Hoeger
Publisher : Cengage Learning
Release : 2021-02-01
ISBN : 0357447484
Language : En, Es, Fr & De

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Book Description :

Take control of your personal well-being with LIFETIME PHYSICAL FITNESS & WELLNESS, 16th Edition. The book shows you how to assess your current behaviors, identify potential problem areas and apply practical steps to start positive changes. Real life stories from other students bring chapter concepts to life. Additionally, hands-on activities help you assess your fitness and wellness level and put chapter concepts into personal practice. Online resources reinforce key concepts through behavior modification planning activities, practice tests, online activities and labs, and a behavior change planner. Empower yourself to make positive changes and improve your health with LIFETIME PHYSICAL FITNESS & WELLNESS. Important Notice: Media content referenced within the product description or the product text may not be available in the ebook version.

Index Medicus

Index Medicus Book
Author : Anonim
Publisher : Unknown
Release : 2004
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Index Medicus book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.