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A Historical Perspective On Evidence Based Immunology

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A Historical Perspective on Evidence Based Immunology

A Historical Perspective on Evidence Based Immunology Book
Author : Edward J. Moticka
Publisher : Newnes
Release : 2015-11-25
ISBN : 0123983754
Language : En, Es, Fr & De

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Book Description :

A Historical Perspective on Evidence-Based Immunology focuses on the results of hypothesis-driven, controlled scientific experiments that have led to the current understanding of immunological principles. The text helps beginning students in biomedical disciplines understand the basis of immunologic knowledge, while also helping more advanced students gain further insights. The book serves as a crucial reference for researchers studying the evolution of ideas and scientific methods, including fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, the generation of diversity and mechanism of tolerance of T cells and B cells, the first cytokines, the concept of autoimmunity, the identification of NK cells as a unique cell type, the structure of antibody molecules and identification of Fab and Fc regions, and dendritic cells. Provides a complete review of the hypothesis-driven, controlled scientific experiments that have led to our current understanding of immunological principles Explains the types of experiments that were performed and how the interpretation of the experiments altered the understanding of immunology Presents concepts such as the division of lymphocytes into functionally different populations in their historical context Includes fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, and the generation of diversity and mechanism of tolerance of T and B cells

The Foundations of Immunology and their Pertinence to Medicine

The Foundations of Immunology and their Pertinence to Medicine Book
Author : Peter Bretscher
Publisher : FriesenPress
Release : 2016-12-07
ISBN : 1460296575
Language : En, Es, Fr & De

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Book Description :

In The Foundations of Immunology and their Pertinence to Medicine, Peter Bretscher describes how the few foundational concepts of immunology came about. He traces Jenner’s development of safe vaccination against small pox in the 1700’s, and how it led to the recognition of infectious disease by Koch and Pasteur in the 1880’s, and to the discovery of the Principles of Vaccination. The formulation of the Clonal Selection Theory in the 1950’s still provides a foundation for contemporary analysis of the immune system. Peter describes the main, and sometimes conflicting concepts, proposed in the last 50 years as to how immune responses are regulated. He develops a unique framework, and employs this to justify some tested and some speculative strategies to prevent and treat clinical conditions in five areas of medicine: Infectious Diseases, Cancer, Autoimmunity, Allergies and Transplantation. This book provides a platform for discussing contemporary immunological issues accessible to the non-specialist, medical students and medical practitioners. The platform challenges some of todays most popular paradigms. Foundations is written in a clear and jargon-free style.

A History of Modern Immunology

A History of Modern Immunology Book
Author : Zoltan A. Nagy
Publisher : Academic Press
Release : 2013-10-11
ISBN : 0124201083
Language : En, Es, Fr & De

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Book Description :

A History of Modern Immunology: A Path Toward Understanding describes, analyzes, and conceptualizes several seminal events and discoveries in immunology in the last third of the 20th century, the era when most questions about the biology of the immune system were raised and also found their answers. Written by an eyewitness to this history, the book gives insight into personal aspects of the important figures in the discipline, and its data driven emphasis on understanding will benefit both young and experienced scientists. This book provides a concise introduction to topics including immunological specificity, antibody diversity, monoclonal antibodies, major histocompatibility complex, antigen presentation, T cell biology, immunological tolerance, and autoimmune disease. This broad background of the discipline of immunology is a valuable companion for students of immunology, research and clinical immunologists, and research managers in the pharmaceutical and biotechnology industries. Contains the history of major breakthroughs in immunology featured with authenticity and insider details Gives an insight into personal aspects of the players in the history of immunology Enables the reader to recognize and select data of heuristic value which elucidate important facets of the immune system Provides good examples and guidelines for the recognition and selection of what is important for the exploration of the immune system Gives clear separation of descriptive and interpretive parts, allowing the reader to distinguish between facts and analysis provided by the author

Avian Immunology

Avian Immunology Book
Author : Karel A. Schat,Bernd Kaspers,Pete Kaiser
Publisher : Academic Press
Release : 2012-12-02
ISBN : 0123972728
Language : En, Es, Fr & De

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Book Description :

The second edition of Avian Immunology provides an up-to-date overview of the current knowledge of avian immunology. From the ontogeny of the avian immune system to practical application in vaccinology, the book encompasses all aspects of innate and adaptive immunity in chickens. In addition, chapters are devoted to the immunology of other commercially important species such as turkeys and ducks, and to ecoimmunology summarizing the knowledge of immune responses in free-living birds often in relation to reproductive success. The book contains a detailed description of the avian innate immune system, encompassing the mucosal, enteric, respiratory and reproductive systems. The diseases and disorders it covers include immunodepressive diseases and immune evasion, autoimmune diseases, and tumors of the immune system. Practical aspects of vaccination are examined as well. Extensive appendices summarize resources for scientists including cell lines, inbred chicken lines, cytokines, chemokines, and monoclonal antibodies. The world-wide importance of poultry protein for the human diet, as well as the threat of avian influenza pandemics like H5N1 and heavy reliance on vaccination to protect commercial flocks makes this book a vital resource. This book provides crucial information not only for poultry health professionals and avian biologists, but also for comparative and veterinary immunologists, graduate students and veterinary students with an interest in avian immunology. With contributions from 33 of the foremost international experts in the field, this book provides the most up-to-date review of avian immunology so far Contains a detailed description of the avian innate immune system reviewing constitutive barriers, chemical and cellular responses; it includes a comprehensive review of avian Toll-like receptors Contains a wide-ranging review of the "ecoimmunology" of free-living avian species, as applied to studies of population dynamics, and reviews methods and resources available for carrying out such research

Systems and Synthetic Immunology

Systems and Synthetic Immunology Book
Author : Shailza Singh
Publisher : Springer Nature
Release : 2020-04-24
ISBN : 9811533504
Language : En, Es, Fr & De

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Book Description :

Systems and Synthetic Immunology focuses on the similarities between biology and engineering at the systems level, which are important for applying engineering theories to biology problems. With the advent of new genomic techniques, there are numerous systematic investigations underway in the scientific world. This volume highlights techniques that can be used to effectively combine two of the most essential biological fields - Systems Biology and Synthetic Immunology. The respective chapters discuss the role of synthetic immunology in biotechnology, production of biomaterials, and their use in vaccine delivery. Further topics include the importance of cytokines; the use of genomic engineering tools in immunotherapy; immunosensors; nanotherapeutics; and bioinformatics tools in biomedical applications. Given its scope, the book offers readers an up-to-date and comprehensive review of this unique and dynamic field of research.

The Immune Response

The Immune Response Book
Author : Tak W. Mak,Mary E. Saunders
Publisher : Academic Press
Release : 2005-11-11
ISBN : 0080534481
Language : En, Es, Fr & De

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Book Description :

The Immune Response is a unique reference work covering the basic and clinical principles of immunology in a modern and comprehensive fashion. Written in an engaging conversational style, the book conveys the broad scope and fascinating appeal of immunology. The book is beautifully illustrated with superb figures as well as many full color plates. This extraordinary work will be an invaluable resource for lecturers and graduate students in immunology, as well as a vital reference for research scientists and clinicians studying related areas in the life and medical sciences. Current and thorough 30 chapter reference reviewed by luminaries in the field Unique ‘single voice' ensures consistency of definitions and concepts Comprehensive and elegant illustrations bring key concepts to life Provides historical context to allow fuller understanding of key issues Introductory chapters 1-4 serve as an ‘Immunology Primer' before topics are discussed in more detail

History of the Basel Institute for Immunology

History of the Basel Institute for Immunology Book
Author : Ivan Lefkovits
Publisher : Unknown
Release : 2017
ISBN : 9783318059342
Language : En, Es, Fr & De

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Book Description :

Lectures, Parties, and Nobel Prizes: living and researching at the Basel Institute for Immunology By the early seventies of the 20th century, the Basel Institute for Immunology had become one of the largest - and certainly the most prominent - immunology institutes in the world. Its lean structure was highly successful, and the quality of the research and its reputation remained outstandingly high throughout the three decades it existed. This book describes the institute's history from its conception and the laying of the foundation stone in 1969 by the pharmaceutical company Roche to the triumph of three Nobel Prizes (1984 and 1987) for Niels K. Jerne, Georges K�hler and Susumu Tonegawa. Can all this be portrayed to make the layman understand it and the scientist relish it? Indeed, the book succeeds in tuning in to what fascinates students, advanced researchers and scientists, historians, policy makers and philanthropists alike. The narrative reveals many aspects of the institute's life and also describes all its research and achievements. Immunologists at every level, from beginners to old hands, will find something of interest to them in this history, and some readers will even make use of the huge database (documents, pictures and films) linked to the book by hundreds of QR codes.

Paul s Fundamental Immunology

Paul s Fundamental Immunology Book
Author : Martin Flajnik
Publisher : Lippincott Williams & Wilkins
Release : 2022-07-19
ISBN : 1975142527
Language : En, Es, Fr & De

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Book Description :

Selected as a Doody's Core Title for 2022! Defining the field of immunology for 40 years, Paul’s Fundamental Immunology continues to provide detailed, authoritative, up-to-date information that uniquely bridges the gap between basic immunology and the disease process. The fully revised 8th edition maintains the excellence established by Dr. William E. Paul, who passed away in 2015, and is now under new editorial leadership of Drs. Martin F. Flajnik, Nevil J. Singh, and Steven M. Holland. It’s an ideal reference and gold standard text for graduate students, post-doctoral fellows, basic and clinical immunologists, microbiologists and infectious disease physicians, and any physician treating diseases in which immunologic mechanisms play a role.

A History of Immunology

A History of Immunology Book
Author : Arthur M. Silverstein
Publisher : Elsevier
Release : 2012-12-02
ISBN : 0080925839
Language : En, Es, Fr & De

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Book Description :

This is a professional-level intellectual history of the development of immunology from about 1720 to about 1970. Beginning with the work and insights of the early immunologists in the 18th century, Silverstein traces the development of the major ideas which have formed immunology down to the maturation of the discipline in the decade following the Second World War. Emphasis is placed on the philosophic and sociologic climate of the scientific milieu in which immunology has developed, providing a background to the broad culture of the discipline. A professional-level intellectual history of the development of immunology from about 1720 to 1970, with emphasis placed on the social climate of the scientific milieu in which modern immunology evolved Written by an author very well known both as a historian of medical science and for his substantial research contributions to the immunopathology of the eye The only complete history of immunology available

The Theory of Endobiogeny

The Theory of Endobiogeny Book
Author : Kamyar M. Hedayat,Jean-Claude Lapraz
Publisher : Academic Press
Release : 2019-06-18
ISBN : 0128173270
Language : En, Es, Fr & De

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Book Description :

The Theory of Endobiogeny Volume 2: Foundational Concepts for Treatments of Common Clinical Conditions addresses the core elements of the adaptation response to stressors: autonomic nervous system (ANS), corticotropic axis, immunity and digestive tract function. The volume is oriented for clinical practice, offering clear discussions on treating the root cause of numerous common disorders, and symptomatically addressing the destabilizing factor in a vast number of disorders ranging from depression to irritable bowel, and from migraines to insomnia called spasmophilia. Extends the concepts of global systems integrative physiology to practical applications in the clinic Detailed explanations of historical, exam and biological modeling indexes related to the ANS, corticotropic axis, hepatobiliary and exocrine pancreatic function Root cause, mechanisms, symptoms and treatments for disorders of immunity, dysbiosis, infectious diseases and spasmophilia, as well as hepatobiliary and pancreatic insufficiency and congestion Materia medica of 22 key medicinal plants with summary of action and indication of usage according to the theory of Endobigoeny Special monodiets and dietary suggestions for disorder discussed

Bionanotechnology

Bionanotechnology Book
Author : Anil Kumar Anal
Publisher : CRC Press
Release : 2018-02-02
ISBN : 1351643630
Language : En, Es, Fr & De

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Book Description :

This book deals with a subject of high interest and importance in all sectors, including biomedical, food, agriculture, energy, and environment. Biological systems are essential in nanotechnology, and many new applications are being developed by mimicking the natural systems. Approaching these topics from an engineering perspective, the book offers insight on the details of nanoscale fabrication processes as well as cell biology. The basics of biology and chemistry, with a focus on how to engineer the behavior of molecules at the nanoscale, are also explored and analyzed. The aim of the text is to provide the reader with broader knowledge of biological methods for signal transduction and molecular recognitions systems and how they can be replicated in bio-sensing applications. The reader will learn the basic structures and interactions of biomacromolecules for developing biocompatible and eco-friendly devices.

Immunology in the Twentieth Century

Immunology in the Twentieth Century Book
Author : Domenico Ribatti
Publisher : Academic Press
Release : 2018-05-11
ISBN : 9780128161456
Language : En, Es, Fr & De

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Book Description :

Immunology in the Twentieth Century: From Basic Science to Clinical Application grew out of common knowledge that those who survived many of the common infectious diseases rarely contracted the same disease again. This book charts the historical development of this vital branch of medicine in a concise volume, covering both the basic science involved and the clinical applications. Immunology as a distinctive subject developed in the mid-twentieth century as researchers started to understand how the adaptive immune system aids the defense against pathogens. The subject has grown in importance and diversified into specialist fields, such as immunohistochemistry, immunogenetics and immunopathology. Provides a concise overhead of the history of immunology and its applications in medicine Includes a discussion of the scientists who were pioneers in landmark discoveries in immunology Summarizes the clinical applications of major discoveries

Introductory Immunology

Introductory Immunology Book
Author : Jeffrey K. Actor
Publisher : Academic Press
Release : 2014-06-16
ISBN : 0124200729
Language : En, Es, Fr & De

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Book Description :

Introductory Immunology quickly acquaints readers with natural immune responses manifesting in diseases and disorders. The book presents a complete picture of natural defenses to infectious agents, as well as the mechanisms that lead to autoimmune dysfunction. In addition, it examines immunologically based diseases, giving the reader sufficient knowledge to make sound clinical decisions leading to better treatment outcomes. Introductory Immunology is aimed at researchers, postgraduates, or any scientifically inclined reader interested in immunology. No prior expertise in medical, biochemical, or cellular science is needed to benefit from the clear presentation of immunology concepts in this book. Quick, concise introduction to immunological concepts Breaks down all of immunology into manageable, logically digestible building blocks Geared toward readers without medical, biochemical, or cellular expertise

Inflammation and the Microcirculation

Inflammation and the Microcirculation Book
Author : D. Neil Granger,Elena Senchenkova
Publisher : Biota Publishing
Release : 2010-06-01
ISBN : 1615041664
Language : En, Es, Fr & De

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Book Description :

The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit characteristic phenotypic changes during inflammation that appear to be directed toward enhancing the delivery of inflammatory cells to the injured/infected tissue, isolating the region from healthy tissue and the systemic circulation, and setting the stage for tissue repair and regeneration. The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets, activation of the coagulation cascade, and enhanced thrombosis, increased vascular permeability, and an increase in the rate of proliferation of blood and lymphatic vessels. A variety of cells that normally circulate in blood (leukocytes, platelets) or reside within the vessel wall (endothelial cells, pericytes) or in the perivascular space (mast cells, macrophages) are activated in response to inflammation. The activation products and chemical mediators released from these cells act through different well-characterized signaling pathways to induce the phenotypic changes in microvessel function that accompany inflammation. Drugs that target a specific microvascular response to inflammation, such as leukocyte-endothelial cell adhesion or angiogenesis, have shown promise in both the preclinical and clinical studies of inflammatory disease. Future research efforts in this area will likely identify new avenues for therapeutic intervention in inflammation.

Infectious

Infectious Book
Author : Dr John S. Tregoning
Publisher : Simon and Schuster
Release : 2021-10-14
ISBN : 0861541235
Language : En, Es, Fr & De

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Book Description :

‘The perfect gift for the armchair epidemiologist’ Wall Street Journal Nature wants you dead. Not just you, but your children and everyone you have ever met and everyone they have ever met; in fact, everyone. It wants you to cough and sneeze and poop yourself into an early grave. It wants your blood vessels to burst and pustules to explode all over your body. And – until recently – it was really good at doing this… The subject of infection and how to fight it grows more urgent every day. How do pathogens cause disease? And what tools can we give our bodies to do battle? Infectious is not only a vital overview of what goes awry in our bodies, but also a hopeful story of ongoing human ingenuity.

Textbook of Immunopsychiatry

Textbook of Immunopsychiatry Book
Author : Golam Khandaker,Neil Harrison,Edward Bullmore,Robert Dantzer
Publisher : Cambridge University Press
Release : 2021-09-23
ISBN : 110842404X
Language : En, Es, Fr & De

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Book Description :

An essential book summarizing cutting-edge evidence on the role of the immune system and immunotherapies in psychiatric disorders.

Tumor Immunology and Immunotherapy

Tumor Immunology and Immunotherapy Book
Author : Robert C. Rees
Publisher : OUP Oxford
Release : 2014-05-29
ISBN : 0191664553
Language : En, Es, Fr & De

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Book Description :

Patients are beginning to benefit from antibody based, cellular and vaccine approaches that are effective against genetically diverse and therapy-resistance cancers. BCG immunotherapy is now being used as a first line treatment for human bladder cancer and the introduction of prophylactic vaccination against Hepatitis B and HPV cancers is starting to show positive results. Following recent FDA approval for a vaccination against prostate cancer, and optimistic results in clinical trials for a vaccine targeting cancer antigens in lung cancer, cancer immunotherapy is now significantly impacting patient clinical management. Tumor Immunology and Immunotherapy provides an up-to-date and comprehensive account of cancer immunity and immunotherapy. It discusses our adaptive and innate immunity to cancer, the mechanisms underpinning our immune response, current approaches to cancer immunotherapy, and how tumour and host responses can circumvent effective anti-cancer immunity. The book examines recent results, publications and current areas of interest including 'immune editing' and the specific issues that are affecting the research and development of vaccines, providing insight into how these problems may be overcome, as viewed by world leaders in the field. Tumor Immunology and Immunotherapy will appeal to clinicians working in oncology and cancer immunotherapy, and research scientists including PhD and masters students, post-doctoral researchers and senior investigators.

Communities in Action

Communities in Action Book
Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice,Committee on Community-Based Solutions to Promote Health Equity in the United States
Publisher : National Academies Press
Release : 2017-04-27
ISBN : 0309452961
Language : En, Es, Fr & De

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Book Description :

In the United States, some populations suffer from far greater disparities in health than others. Those disparities are caused not only by fundamental differences in health status across segments of the population, but also because of inequities in factors that impact health status, so-called determinants of health. Only part of an individual's health status depends on his or her behavior and choice; community-wide problems like poverty, unemployment, poor education, inadequate housing, poor public transportation, interpersonal violence, and decaying neighborhoods also contribute to health inequities, as well as the historic and ongoing interplay of structures, policies, and norms that shape lives. When these factors are not optimal in a community, it does not mean they are intractable: such inequities can be mitigated by social policies that can shape health in powerful ways. Communities in Action: Pathways to Health Equity seeks to delineate the causes of and the solutions to health inequities in the United States. This report focuses on what communities can do to promote health equity, what actions are needed by the many and varied stakeholders that are part of communities or support them, as well as the root causes and structural barriers that need to be overcome.

Crafting Immunity

Crafting Immunity Book
Author : Jennifer Keelan
Publisher : Routledge
Release : 2017-03-02
ISBN : 1351947893
Language : En, Es, Fr & De

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Book Description :

Immunity is as old as illness itself, yet historians have only just begun to take up the challenge of reconstructing the modern transformation of attempts to protect against disease. Crafting Immunity assembles in one volume the most recent efforts of an international group of scholars to place the diverse practices of immunity in their historical contexts. It is this diversity that provides the book with its greatest source of strength. Collectively, the papers in this volume suggest that it was the craft-like, small-scale, and local conditions of clinical medicine that turned the immunity of individuals and populations into biomedical objects. That is to say, the modern conception of immunity was at least as much the product of the work of healing as it was the systematic result of discoveries about the immune system. Working outside the narrow confines of laboratory histories, Crafting Immunity is the first attempt to set the problems of immunity into a variety of social, technological, institutional and intellectual contexts. It will appeal not only to historians and sociologists of health, but also to social and cultural historians interested in the biomedical creation of modern health regimens.

The Link Between Religion and Health

The Link Between Religion and Health Book
Author : Harold George Koenig,Harvey Jay Cohen
Publisher : Oxford University Press, USA
Release : 2002
ISBN : 0195143604
Language : En, Es, Fr & De

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Book Description :

Psychoneuroimmunology (PNI) studies relationships between mental state & the nervous, endocrine & immune systems. It focuses on how mental states & beliefs affect physical health. This book examines topics relating to religious faith & behaviour.