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3d Bioprinting And Nanotechnology In Tissue Engineering And Regenerative Medicine

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3D Bioprinting and Nanotechnology in Tissue Engineering and Regenerative Medicine

3D Bioprinting and Nanotechnology in Tissue Engineering and Regenerative Medicine Book
Author : Lijie Grace Zhang,John P Fisher,Kam Leong
Publisher : Academic Press
Release : 2015-01-14
ISBN : 0128006641
Language : En, Es, Fr & De

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Book Description :

3D Bioprinting and Nanotechnology in Tissue Engineering provides an in depth introduction to these two technologies and their industrial applications. Stem cells in tissue regeneration are covered, along with nanobiomaterials. Commercialization, legal and regulatory considerations are also discussed in order to help you translate nanotechnology and 3D printing-based products to the marketplace and the clinic. Dr. Zhang’s and Dr. Fishers’ team of expert contributors have pooled their expertise in order to provide a summary of the suitability, sustainability and limitations of each technique for each specific application. The increasing availability and decreasing costs of nanotechnologies and 3D printing technologies are driving their use to meet medical needs, and this book provides an overview of these technologies and their integration. It shows how nanotechnology can increase the clinical efficiency of prosthesis or artificial tissues made by bioprinting or biofabrication. Students and professionals will receive a balanced assessment of relevant technology with theoretical foundation, while still learning about the newest printing techniques. Includes clinical applications, regulatory hurdles, and risk-benefit analysis of each technology. This book will assist you in selecting the best materials and identifying the right parameters for printing, plus incorporate cells and biologically active agents into a printed structure Learn the advantages of integrating 3D printing and nanotechnology in order to improve the safety of your nano-scale materials for biomedical applications

Biomimetic Medical Materials

Biomimetic Medical Materials Book
Author : Insup Noh
Publisher : Springer
Release : 2018-11-23
ISBN : 9811304459
Language : En, Es, Fr & De

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Book Description :

This volume outlines the current status in the field of biomimetic medical materials and illustrates research into their applications in tissue engineering. The book is divided into six parts, focusing on nano biomaterials, stem cells, tissue engineering, 3D printing, immune responses and intellectual property. Each chapter has its own introduction and outlines current research trends in a variety of applications of biomimetic medical materials. The biomimetic medical materials that are covered include functional hydrogels, nanoparticles for drug delivery and medicine, the 3D bioprinting of biomaterials, sensor materials, stem cell interactions with biomaterials, immune responses to biomaterials, biodegradable hard scaffolds for tissue engineering, as well as other important topics, like intellectual property. Each chapter is written by a team of experts. This volume attempts to introduce the biomimetic properties of biomedical materials within the context of our current understanding of the nanotechnology of nanoparticles and fibres and the macroscopic aspects of 3D bioprinting.

Biomaterials in Tissue Engineering and Regenerative Medicine

Biomaterials in Tissue Engineering and Regenerative Medicine Book
Author : Birru Bhaskar,Parcha Sreenivasa Rao,Naresh Kasoju,Vasagiri Nagarjuna,Rama Raju Baadhe
Publisher : Springer
Release : 2021-04-22
ISBN : 9789811600012
Language : En, Es, Fr & De

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Book Description :

This book comprehensively explores the basic concepts and applications of biomaterials in tissue engineering and regenerative medicine. The book is divided into four sections; the first section deals with the basic concepts and different types of biomaterials used in tissue engineering. The second section discusses the functional requirements and types of materials that are used in developing state-of-the-art of scaffolds for tissue engineering applications. The third section presents the applications of biomaterials for hard and soft tissue engineering, as well as for specialized tissue engineering. The last section addresses the future prospects of nanobiomaterials, intelligent biomaterials, and 3D bioprinting biomaterials in tissue engineering and regenerative medicine. It also discusses various in vitro disease models for tissue bioengineering and regenerative medicine. As such, it offers a valuable resource for students, researchers, scientists, entrepreneurs, and medical/healthcare professionals.

3D Bioprinting in Regenerative Engineering

3D Bioprinting in Regenerative Engineering Book
Author : Ali Khademhosseini,Gulden Camci-Unal
Publisher : CRC Press
Release : 2018-04-17
ISBN : 1315280485
Language : En, Es, Fr & De

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Book Description :

Regenerative engineering is the convergence of developmental biology, stem cell science and engineering, materials science, and clinical translation to provide tissue patches or constructs for diseased or damaged organs. Various methods have been introduced to create tissue constructs with clinically relevant dimensions. Among such methods, 3D bioprinting provides the versatility, speed and control over location and dimensions of the deposited structures. Three-dimensional bioprinting has leveraged the momentum in printing and tissue engineering technologies and has emerged as a versatile method of fabricating tissue blocks and patches. The flexibility of the system lies in the fact that numerous biomaterials encapsulated with living cells can be printed. This book contains an extensive collection of papers by world-renowned experts in 3D bioprinting. In addition to providing entry-level knowledge about bioprinting, the authors delve into the latest advances in this technology. Furthermore, details are included about the different technologies used in bioprinting. In addition to the equipment for bioprinting, the book also describes the different biomaterials and cells used in these approaches. This text: Presents the principles and applications of bioprinting Discusses bioinks for 3D printing Explores applications of extrusion bioprinting, including past, present, and future challenges Includes discussion on 4D Bioprinting in terms of mechanisms and applications

Advanced 3D Printed Systems and Nanosystems for Drug Delivery and Tissue Engineering

Advanced 3D Printed Systems and Nanosystems for Drug Delivery and Tissue Engineering Book
Author : Lisa C. du Toit,Pradeep Kumar,Yahya E. Choonara,Viness Pillay
Publisher : Elsevier
Release : 2020-03-08
ISBN : 0128184728
Language : En, Es, Fr & De

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Book Description :

Advanced 3D-Printed Systems and Nanosystems for Drug Delivery and Tissue Engineering explores the intricacies of nanostructures and 3D printed systems in terms of their design as drug delivery or tissue engineering devices, their further evaluations and diverse applications. The book highlights the most recent advances in both nanosystems and 3D-printed systems for both drug delivery and tissue engineering applications. It discusses the convergence of biofabrication with nanotechnology, constructing a directional customizable biomaterial arrangement for promoting tissue regeneration, combined with the potential for controlled bioactive delivery. These discussions provide a new viewpoint for both biomaterials scientists and pharmaceutical scientists. Shows how nanotechnology and 3D printing are being used to create systems which are intelligent, biomimetic and customizable to the patient Explores the current generation of nanostructured 3D printed medical devices Assesses the major challenges of using 3D printed nanosystems for the manufacture of new pharmaceuticals

Cutting Edge Enabling Technologies for Regenerative Medicine

Cutting Edge Enabling Technologies for Regenerative Medicine Book
Author : Heung Jae Chun,Chan Hum Park,Il Keun Kwon,Gilson Khang
Publisher : Springer
Release : 2018-10-24
ISBN : 9811309507
Language : En, Es, Fr & De

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Book Description :

This book explores in depth the latest enabling technologies for regenerative medicine. The opening section examines advances in 3D bioprinting and the fabrication of electrospun and electrosprayed scaffolds. The potential applications of intelligent nanocomposites are then considered, covering, for example, graphene-based nanocomposites, intrinsically conductive polymer nanocomposites, and smart diagnostic contact lens systems. The third section is devoted to various drug delivery systems and strategies for regenerative medicine. Finally, a wide range of future enabling technologies are discussed. Examples include temperature-responsive cell culture surfaces, nanopatterned scaffolds for neural tissue engineering, and process system engineering methodologies for application in tissue development. This is one of two books to be based on contributions from leading experts that were delivered at the 2018 Asia University Symposium on Biomedical Engineering in Seoul, Korea – the companion book examines in depth novel biomaterials for regenerative medicine.

3D Bioprinting in Medicine

3D Bioprinting in Medicine Book
Author : Murat Guvendiren
Publisher : Springer
Release : 2019-08-02
ISBN : 3030239063
Language : En, Es, Fr & De

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Book Description :

This book provides current and emerging developments in bioprinting with respect to bioprinting technologies, bioinks, applications, and regulatory pathways. Topics covered include 3D bioprinting technologies, materials such as bioinks and bioink design, applications of bioprinting complex tissues, tissue and disease models, vasculature, and musculoskeletal tissue. The final chapter is devoted to clinical applications of bioprinting, including the safety, ethical, and regulatory aspects. This book serves as a go-to reference on bioprinting and is ideal for students, researchers and professionals, including those in academia, government, the medical industry, and healthcare.

Biomedical Nanomaterials

Biomedical Nanomaterials Book
Author : Thomas J. Webster,Hilal Yazici
Publisher : Unknown
Release : 2016
ISBN : 9781849199650
Language : En, Es, Fr & De

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Book Description :

Nanomaterials are able to penetrate nanoscale pores of tissues, possess prolonged circulation, enter cells, and have increased surface area per volume allowing for greater drug loading. For these reasons, nanomaterials are finding numerous uses in medicine including fighting cancer, promoting tissue regeneration, reversing aging, inhibiting infection, limiting inflammation or scar tissue growth, and many others. This book describes the engineering applications and challenges of using nanostructured surfaces and nanomaterials in healthcare. Topics covered include biomimetic coating of calcium phosphates on Ti metals; surface modifications of orthopedic implant materials using an electroplating process; design, fabrication and application of carbon-based nano biomaterials; usage of stem cells in bone and cartilage tissue engineering; nanobiomaterials and 3D bioprinting for osteochondral regeneration; self- assembled peptide hydrogels for biomedical applications; antimicrobial properties of nanomaterials; nanoparticle enhanced radiation therapy for bacterial infection; nanomaterials used in implant technology and their toxicity; challenges of risk assessment of nanomaterials in consumer products and current regulatory status; and the clinical rationale for silicon nitride bioceramics in orthopedics. With contributions from an international selection of researchers this book is essential reading for researchers in industry and academia working at the interfaces of healthcare, engineering and nanotechnology.

Cardiovascular Regenerative Medicine

Cardiovascular Regenerative Medicine Book
Author : Vahid Serpooshan,Sean M. Wu
Publisher : Springer
Release : 2019-06-29
ISBN : 3030200477
Language : En, Es, Fr & De

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Book Description :

This book is a comprehensive and up-to-date resource on the use of regenerative medicine for the treatment of cardiovascular disease. It provides a much-needed review of the rapid development and evolution of bio-fabrication techniques to engineer cardiovascular tissues as well as their use in clinical settings. The book incorporates recent advances in the biology, biomaterial design, and manufacturing of bioengineered cardiovascular tissue with their clinical applications to bridge the basic sciences to current and future cardiovascular treatment. The book begins with an examination of state-of-the-art cellular, biomaterial, and macromolecular technologies for the repair and regeneration of diseased heart tissue. It discusses advances in nanotechnology and bioengineering of cardiac microtissues using acoustic assembly. Subsequent chapters explore the clinical applications and translational potential of current technologies such as cardiac patch-based treatments, cell-based regenerative therapies, and injectable hydrogels. The book examines how these methodologies are used to treat a variety of cardiovascular diseases including myocardial infarction, congenital heart disease, and ischemic heart injuries. Finally, the volume concludes with a summary of the most prominent challenges and perspectives on the field of cardiovascular tissue engineering and clinical cardiovascular regenerative medicine. Cardiovascular Regenerative Medicine is an essential resource for physicians, residents, fellows, and medical students in cardiology and cardiovascular regeneration as well as clinical and basic researchers in bioengineering, nanomaterial and technology, and cardiovascular biology.

Biofabrication

Biofabrication Book
Author : Bertrand Guillotin,Muhammad Ali,Alexandre Ducom,Sylvain Catros,Virginie Keriquel,Agnès Souquet,Murielle Remy,Jean-Christophe Fricain,Fabien Guillemot
Publisher : Elsevier Inc. Chapters
Release : 2013-03-18
ISBN : 0128090537
Language : En, Es, Fr & De

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Book Description :

Laser-assisted bioprinting (LAB) is an emerging technology in the field of tissue engineering. Its physical mechanism makes it possible to print cells and liquid materials with a cell-level resolution. By giving tissue engineers control over cell density and organization of 3D tissue constructs, LAB holds much promise for fabricating living tissues with physiological functionality. After introducing the rationale of applying LAB to tissue engineering, we present exhaustively the physical parameters related to the laser-induced forward transfer technique (LIFT), which is implemented in LAB. These parameters are critical to controlling the cell printing process and must work together to print viable cell patterns with respect to cell-level histological organization and to high-throughput manufacturing. After describing the experimental requirements that should be considered to fabricate 3D tissues by LAB, we present some of the main breakthroughs, including multicomponent printing, 3D printing approaches, and bioprinting in vivo that may serve in tissue engineering and regenerative medicine.

Essentials of 3D Biofabrication and Translation

Essentials of 3D Biofabrication and Translation Book
Author : Anthony Atala,James J Yoo
Publisher : Academic Press
Release : 2015-07-17
ISBN : 0128010150
Language : En, Es, Fr & De

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Book Description :

Essentials of 3D Biofabrication and Translation discusses the techniques that are making bioprinting a viable alternative in regenerative medicine. The book runs the gamut of topics related to the subject, including hydrogels and polymers, nanotechnology, toxicity testing, and drug screening platforms, also introducing current applications in the cardiac, skeletal, and nervous systems, and organ construction. Leaders in clinical medicine and translational science provide a global perspective of the transformative nature of this field, including the use of cells, biomaterials, and macromolecules to create basic building blocks of tissues and organs, all of which are driving the field of biofabrication to transform regenerative medicine. Provides a new and versatile method to fabricating living tissue Discusses future applications for 3D bioprinting technologies, including use in the cardiac, skeletal, and nervous systems, and organ construction Describes current approaches and future challenges for translational science Runs the gamut of topics related to the subject, from hydrogels and polymers to nanotechnology, toxicity testing, and drug screening platforms

3D Printing of Functional Biomaterials for Tissue Modeling

3D Printing of Functional Biomaterials for Tissue Modeling Book
Author : Wei Zhu
Publisher : Unknown
Release : 2016
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

3D bioprinting is emerging as a promising tool in the tissue engineering field, providing bioengineering researchers with the unprecedented capability to engineer complex 3D biological architectures. However, there are still significant technological challenges for the existing bioprinting platforms to meet the various requirements of bioprinting functional tissue constructs and biomedical devices, from the aspects of resolution, speed, flexibility and scalability. In this dissertation, we develop and explore the applications of an advanced rapid bioprinting platform based on digital light projection technology--microscale continuous optical bioprinting ([mu]COB). First of all, we utilize the [mu]COB system to generate simple physical patterns to investigate the relative impact of cell alignment and form-induced stress on the differentiation of adipose derived stem cells (ADSCs). Secondly, we move towards the printing of more complex biomimetic scaffolds for the treatment of spinal cord injury. We show that patient specific scaffolds can be printed for precision medicine. The bioprinted scaffolds can also be loaded with neural stem cells to guide and promote the regeneration of spinal cord. Then we incorporated live cell encapsulation in the bioprinting process to build prevascularized tissues. We show the survival and progressive formation of the endothelial network both in vitro and in vivo. Next we further examine the possibility of 3D printing homogeneous hydrogel nanocomposites with functional nanoparticles. A liver-inspired 3D detoxification device is created with nanoparticles that can attract, capture and sense toxins. Lastly, we explore the printing of multiple types of nanoparticles with heterogeneous distribution to create artificial microfish. With the functional nanoparticles, the printed microfish can be chemically driven and magnetically guided for detoxification applications. Overall, this work presents an advanced rapid bioprinting platform, capable of fabricating various intricate biomimetic structures with a variety of biomaterials, cells, and functional nanoparticles for tissue engineering and biomedical research.

Racing for the Surface

Racing for the Surface Book
Author : Bingyun Li,Thomas Fintan Moriarty,Thomas Webster,Malcolm Xing
Publisher : Springer Nature
Release : 2020-02-28
ISBN : 3030344711
Language : En, Es, Fr & De

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Book Description :

This book covers the key basics of tissue engineering as well as the latest advances in the integration of both antimicrobial and osteoinductive properties. Topics covered include osteoconductive and osteoinductive biomaterials (calcium phosphate, bone morphogenetic protein, peptides, antibodies, bioactive glasses, nanomaterials, etc.) and scaffolds. Research integrating both antimicrobial/biofilm-inhibiting and osteoinductive/osteoconductive properties and their co-delivery is detailed and their roles in clinical success are discussed. Combined with its companion volume, Racing for the Surface: Antimicrobial and Interface Tissue Engineering, this book bridges the gap between infection and tissue engineering, and is an ideal book for academic researchers, clinicians, industrial engineers and scientists, governmental representatives in national laboratories, and advanced undergraduate students and post-doctoral fellows who are interested in tissue engineering and regeneration, infection, and biomaterials and devices.

Tissue Engineering Strategies for Organ Regeneration

Tissue Engineering Strategies for Organ Regeneration Book
Author : Naznin Sultana,Sanchita Bandyopadhyay-Ghosh,Chin Fhong Soon
Publisher : CRC Press
Release : 2020
ISBN : 9781138391543
Language : En, Es, Fr & De

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Book Description :

Tissue Engineering Strategies for Organ Regeneration addresses the existing and future trends of tissue engineering approaches for organ/tissue regeneration or repair. This book provides a comprehensive summary of the recent improvement of biomaterials used in scaffold-based tissue engineering, and the tools and different protocols needed to design tissues and organs. The chapters in this book provide the in-depth principles for many of the supporting and enabling technologies including the applications of BioMEMS devices in tissue engineering, and the combination of organoid formation and three dimensional (3D) bioprinting. The book also highlights the advances and strategies for regeneration of three-dimensional microtissues in microcapsules, tissue reconstruction techniques, and injectable composite scaffolds for bone tissue repair and augmentation. Key Features: Addresses the current obstacles to tissue engineering applications Provides the latest improvements in the field of integrated biomaterials and fabrication techniques for scaffold-based tissue engineering Shows the influence of microenvironment towards cell-biomaterials interactions Highlights significant and recent improvements of tissue engineering applications for the artificial organ and tissue generation Describes the applications of microelectronic devices in tissue engineering Describes different current bioprinting technologies

Neural Engineering

Neural Engineering Book
Author : Lijie Grace Zhang,David L. Kaplan
Publisher : Springer
Release : 2016-06-29
ISBN : 3319314335
Language : En, Es, Fr & De

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Book Description :

This book covers the principles of advanced 3D fabrication techniques, stem cells and biomaterials for neural engineering. Renowned contributors cover topics such as neural tissue regeneration, peripheral and central nervous system repair, brain-machine interfaces and in vitro nervous system modeling. Within these areas, focus remains on exciting and emerging technologies such as highly developed neuroprostheses and the communication channels between the brain and prostheses, enabling technologies that are beneficial for development of therapeutic interventions, advanced fabrication techniques such as 3D bioprinting, photolithography, microfluidics, and subtractive fabrication, and the engineering of implantable neural grafts.There is a strong focus on stem cells and 3D bioprinting technologies throughout the book, including working with embryonic, fetal, neonatal, and adult stem cells and a variety of sophisticated 3D bioprinting methods for neural engineering applications. There is also a strong focus on biomaterials, including various conductive biomaterials and biomimetic nanomaterials such as carbon-based nanomaterials and engineered 3D nanofibrous scaffolds for neural tissue regeneration. Finally, two chapters on in vitro nervous system models are also included, which cover this topic in the context of studying physiology and pathology of the human nervous system, and for use in drug discovery research. This is an essential book for biomedical engineers, neuroscientists, neurophysiologists, and industry professionals.

Current Advances in Oral and Craniofacial Tissue Engineering

Current Advances in Oral and Craniofacial Tissue Engineering Book
Author : Vincenzo Guarino,Marco Antonio Alverez-Perez
Publisher : CRC Press
Release : 2020-11-13
ISBN : 042975082X
Language : En, Es, Fr & De

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Book Description :

Oral tissue engineering involves the study of current approaches for in vitro regeneration of soft and hard tissues located into the oral cavity. In this context, recent approaches involves the use of innovative biomaterials to replace the lost or damaged human oral tissues. Recent discoveries in materials science and nanotechnology are drastically changing the traditional approach to dentistry by the design of innovative devices able more efficiently supporting the natural regeneration process. The objective of this book is to highlight current progress in tissue engineering for various dental hard/soft tissues including enamel, dentin, pulp, alveolar bone, periodontium, gum and oral mucosa, by emphasizing the role of materials and their specific applications.

Cell derived Matrices Part A

Cell derived Matrices Part A Book
Author : Anonim
Publisher : Academic Press
Release : 2020-03-26
ISBN : 0128201738
Language : En, Es, Fr & De

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Book Description :

Cell-Derived Matrices, Part A, Volume 156, provides a detailed description and step-by-step methods surrounding the use of three-dimensional cell-derived matrices for tissue engineering applications. Biochemical, biophysical and cell biological approaches are presented, along with sample results. Specific chapters cover Anisotropic cell-derived matrices with controlled 3D architecture, Generation of functional fluorescently-labelled cell-derived matrices by means of genetically-modified fibroblasts, Bi-layered cell-derived matrices, Engineering clinically-relevant cell-derived matrices using primary fibroblasts, Decellularized matrices for bioprinting applications, and much more. Contains contributions from leading experts in the field from across the globe Covers a wide array of topics on the use of cell-derived matrices for tissue engineering and regenerative medicine applications Includes relevant, analysis-based topics, such as quantification of the mechanical properties, decellularization protocols, and innovative matrix engineering methods

Cell derived Matrices

Cell derived Matrices Book
Author : Rui L. Reis
Publisher : Academic Press
Release : 2020-03-24
ISBN : 012820172X
Language : En, Es, Fr & De

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Book Description :

Cell-Derived Matrices, Part A, Volume 156, provides a detailed description and step-by-step methods surrounding the use of three-dimensional cell-derived matrices for tissue engineering applications. Biochemical, biophysical and cell biological approaches are presented, along with sample results. Specific chapters cover Anisotropic cell-derived matrices with controlled 3D architecture, Generation of functional fluorescently-labelled cell-derived matrices by means of genetically-modified fibroblasts, Bi-layered cell-derived matrices, Engineering clinically-relevant cell-derived matrices using primary fibroblasts, Decellularized matrices for bioprinting applications, and much more.

Technological Advances in Organ Transplantation

Technological Advances in Organ Transplantation Book
Author : Satish N. Nadig,Jason A. Wertheim
Publisher : Springer
Release : 2018-05-23
ISBN : 3319621424
Language : En, Es, Fr & De

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Book Description :

This book provides an expert view into the current technologies that are revolutionizing the field of solid organ transplantation. This unique book provides insight into progress made in areas spanning robotic surgery to tissue engineering and also gives a glimpse into what may lie ahead for this innovative specialty. Topics covered include nanotherapy, machine perfusion, artificial organ development, robotics in transplant surgery, mobile health technology, stem cell therapy, and ex vivo repair of organs. This is an ideal book for biomedical engineers, physicians and surgeons, general and transplant surgeons, medical students, medical and surgical trainees, and transplant procurement technicians.

Biomimetic Nanoengineered Materials for Advanced Drug Delivery

Biomimetic Nanoengineered Materials for Advanced Drug Delivery Book
Author : Afeesh Rajan Unnithan,Arathyram Ramachandra Kurup Sasikala,Cheol Sang Kim,Chan Hee Park
Publisher : Unknown
Release : 2019-10
ISBN : 9780128149447
Language : En, Es, Fr & De

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Book Description :

Biomimetic Nanoengineered Materials for Advanced Drug Delivery is an indispensable guide for new developments in biomimetic nanoengineering for advanced drug delivery applications. Focusing on the fundamentals of a new type of nanocarriers for drug delivery in the most recent miRNA therapeutics, the book provides readers with detailed knowledge from the basics, to the most recent innovations. Early chapters of the book discuss a range of drug delivery techniques, including nanofibers, biomimetic polymers, 3D bioprinting, nanotechnology and radiofrequency sensitive nanocarriers. Later chapters explore miRNA therapeutics, magnetic nanoparticles, nanogel-based and ROS-mediated drug delivery systems. The book is a vital reference for biomaterials and nanomedicine researchers and clinicians with an interest in advanced drug delivery. Analyzes nanoparticle-plasma protein interactions, making it one of the first books on this topic Includes the latest trends in nanotherapeutic drug delivery Presents comprehensive chapters that cover a specific drug delivery carrier and its mode of operation, stimuli and the target site of action Provides an essential tool for researchers in nanomedicine and nanobiomaterials